Summary

The research interest of our group focuses on Helicobacter pylori, a highly diverse bacterial species that colonises the gastric mucosa of humans. Infection with these bacteria is associated with distinct clinical outcomes such as chronic gastritis, peptic ulcer disease and gastric cancer. H. pylori virulence factors constitute an important source of variation in the outcome of the infection and are responsible for diverse cellular responses.

We are particularly interested in: (1) the epidemiology and clinical relevance of H. pylori virulence factors and; (2) the role of H. pylori virulence factors on epithelial cell responses relevant to gastric carcinogenesis.